Endocrine Abstracts

Anemia occurs early and predicts high risk of cardiovascular events and death in patients with diabetic nephropathy (DN). It results from various factors including erythropoietin (EPO) deficiency and inflammation. The aim of this study was to evaluate clinical correlates of TNF alpha levels in anemic patients with early diabetic nephropathy. We investigated 95 anemic patients with type 2 diabetes mellitus and chronic kidney disease (stages 1–3). Glomerular filtration rate...

Anemia occurs early and predicts high risk of cardiovascular events and death in patients with diabetic nephropathy (DN). It results from various factors including erythropoietin (EPO) deficiency and inflammation. The aim of this study was to evaluate clinical correlates of TNF alpha levels in anemic patients with early diabetic nephropathy. We investigated 95 anemic patients with type 2 diabetes mellitus and chronic kidney disease (stages 1–3). Glomerular filtration rate...

Materials and methods: A survey was 95 people (45 people with diabetes mellitus type 1, 50 people with diabetes mellitus type 2). The age of examined patients 39.12±3.8. The disease duration ranged from 6 to 20 years. Level of biochemical indicators – normal limits. Condition of mineral density of a bone tissue it was estimated by method of a dual-energy X-ray absorptiometry (DEXA). The analysis of DEXA researches showed that change of mineral density of a bone tissu...

Aims: Anaemia occurs early and predicts high risk of cardiovascular events and death in patients with diabetic nephropathy. In our previous studies we have shown that haemoglobin level has a negative correlation with serum levels of proinflammatory cytokines in this clinical group. It could be hypothesised that treatment of anaemia has anti-inflammatory effects. The aim of this study was to assess the influence of treatment with erythropoietin alpha on serum level of tumour ne...

Introduction: Anemia is associated with an increased risk of cardiovascular events and death in patients with diabetic nephropathy (DN). However, there are still a lot of contradictions related to the benefits and risks of antianemic treatment in this group of patients due to variety of non-hematopoietic effects of erythropoietin. The aim of this study was to assess the influence of erythropoietin therapy on renal function and proteinuria in patients with early DN.<p class...

There is growing evidence that platelet indices correlate with functional status of platelets and with the risk of cardiovascular events. In this study we aimed to assess clinical correlates of mean platelet volume (MPV) in patients with abdominal obesity from different age groups. We investigated 111 adults with abdominal obesity, not receiving antiplatelet therapy. Abdominal obesity was defined in accordance with IDF criteria (2006). Group 1 included 44 patients aged 26&#150...

Aims: Anemia occurs early and predicts high risk of cardiovascular events and death in patients with diabetic nephropathy. The aim of this study was to assess the influence of anemia on the quality of life of patients with early diabetic nephropathy.Methods: We investigated 95 anemic and 32 non-anemic patients with type 2 diabetes mellitus and early diabetic nephropathy (CKD stages 1–3). Anemia was defined according to WHO criteria. Anemic patients ...

Proinflammmatory cytokines including interferon gamma (IFNg) are known to be involved in the pathogenesis of diabetic nephropathy. The aim of this study was to assess serum level of IFNg and its clinical correlates in patients with type 2 diabetes and early CKD receiving different types of treatment. We investigated 64 patients with type 2 diabetes and CKD stages 1-3. Group 1 included 20 patients on insulin therapy. Group 2 included 44 patients on metformin or combined oral hy...